ABSTRACT
A difilobotríase é uma moléstia intestinal provocada por cestódeos do gênero Diphyllobothrium (tênia) que até pouco tempo havia poucos relatos em nosso país. Porém, em decorrência do aumento do consumo de peixes crus, mal cozidos ou defumados e da falta de cuidado nos seus preparos, vêm sendo identificados casos autóctones no Brasil. O número de pessoas parasitadas pelo platelminto difilobotríase, presente em várias regiões do mundo, vem aumentando desde 2003. A doença pode ser assintomática ou causar desconforto abdominal e interferir na absorção da vitamina B12, podendo causar anemia megaloblástica. Abster-se do consumo de pescado cru, defumado em temperaturas inadequadas ou mal cozido é a principal medida para a sua prevenção.
The intestinal diphyllobotriasis is a disease caused by Diphyllobothrium (cestodes of the genus Taenia [tapeworm]) that until recently had a few reports in our country. However, as a result of increased consumption of raw fish, soft-boiled or smoked and lack of care in their staging have been identified indigenous cases in Brazil. The number of people by the flatworm diphyllobotriasis parasitized, present in various regions of the world, comes increasing since 2003. The disease may be asymptomatic or cause abdominal discomfort and interferes in the absorption of vitamin B12, leading to megaloblastic anemia. Avoid from eating raw, smoked or soft-boiled fish is the primaries beware of their prevention.
Subject(s)
Humans , Male , Female , Food Contamination/analysis , Diphyllobothriasis/diagnosis , Diphyllobothriasis/etiology , Diphyllobothriasis/prevention & control , Diphyllobothriasis/therapy , Diphyllobothrium/parasitology , Food Microbiology , Helminths/parasitology , Fishes/parasitology , Salmon/parasitology , Anemia, Megaloblastic/etiology , Health Education/trendsABSTRACT
Após 100 anos da descrição do Trypanosoma cruzi, a moléstia de Chagas permanece como um grande desafio, em termos de saúde pública, para os países da América Latina. Entre os pontos que merecem reflexão, neste âmbito, está a necessidade de se repensar a enfermidade sob uma perspectiva evolutiva ? com base nas ideias de deriva genética, mutação e seleção natural ? e ecológica, tendo em vista a incorporação dos referenciais da educação ambiental e da educação em saúde, elementos que poderão contribuir decisivamente para o controle da doença.
100 years after the description of the Trypanosoma cruzi, Chagas? disease remains a public health challenge among the countries of Latin America. One of the points that demand reflection, in this context, is the need to rethink the disease under a evolutionary perspective ? based on ideas of genetic derivation, mutation and natural selection ? and ecological, regarding environmental education and health education interactions, elements that may contribute decisively to the control of the disease.
ABSTRACT
We evaluated the use of a combination of vitamins B1, B6, and B12 with dexamethasone in the treatment of the signs and symptoms of inflammatory neuropathy of the upper and lower limbs, in an open-label clinical trial. Patients were submitted to a 9-day treatment period with three doses of study medication at three day intervals, and a series of clinical and laboratory assessments, prior to the first dose of study medication and at each of the following three visits to the study center. Efficacy evaluations at each study visit included a 100mm VAS pain scale and global and satisfaction surveys completed by the patient and the investigating physician. Safety evaluations included a comparison of changes in laboratory evaluations at each visit and the incidence, severity, duration, and outcome of adverse events. A total of sixty-one patients were enrolled in the trial. A clinically significant improvement in all of the efficacy measures was observed from the pre-treatment to end-of-study evaluations. No clinically significant alterations in clinical assessments were observed during the treatment period. Based on the results of this clinical study, we conclude that the combination of dexamethasone with the B-vitamins is safe and effective in the treatment of the signs and symptoms of inflammatory neuropathy.